AS3MT
Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene.[1][2]
References
References
- ↑ Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (March 2002). “A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol”. The Journal of Biological Chemistry. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.
- ↑ “Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase”.
Further reading
Further reading
- Dheeman DS, Packianathan C, Pillai JK, Rosen BP (November 2014). “Pathway of human AS3MT arsenic methylation”. Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC 4237493. PMID 25325836.
- Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (April 2008). “High arsenic metabolic efficiency in AS3MT287Thr allele carriers”. Pharmacogenetics and Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919.
- Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (December 2007). “Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method”. Toxicology and Applied Pharmacology. 225 (3): 251–4. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
- Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (January 2008). “Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile”. Mutation Research. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
- Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (July 2007). “Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms”. Environmental Health Perspectives. 115 (7): 1081–6. doi:10.1289/ehp.10026. PMC 1913583. PMID 17637926.
- Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (April 2007). “Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina”. Environmental Health Perspectives. 115 (4): 599–605. doi:10.1289/ehp.9734. PMC 1852682. PMID 17450230.
- Meza M, Gandolfi AJ, Klimecki WT (August 2007). “Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?”. Toxicology and Applied Pharmacology. 222 (3): 381–7. doi:10.1016/j.taap.2006.12.018. PMC 2040165. PMID 17306849.
- Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (March 2006). “Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies”. The Journal of Biological Chemistry. 281 (11): 7364–73. doi:10.1074/jbc.M512227200. PMID 16407288.
- Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (June 2005). “Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children”. Environmental Health Perspectives. 113 (6): 775–81. doi:10.1289/ehp.7780. PMC 1257606. PMID 15929903.
- Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (April 2005). “Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype”. Toxicology and Applied Pharmacology. 204 (2): 164–9. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
External links
- Human AS3MT genome location and AS3MT gene details page in the UCSC Genome Browser.
Looking for the patient version?
© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH