Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
AZGP1
Introduction
Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.[1][2]
This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.[3] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[3] Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter.
References
References
- ↑ Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). “Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene”. Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092.
- ↑ “Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding”.
- ↑ 3.0 3.1 Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH; et al. (2009). “Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human”. Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC 2679098. PMID 19188554.
External links
External links
- Human AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Freije JP, Fueyo A, UrÃa J, López-OtÃn C (1991). “Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues”. FEBS Lett. 290 (1–2): 247–9. doi:10.1016/0014-5793(91)81271-9. PMID 1915885.
- Tada T, Ohkubo I, Niwa M, et al. (1991). “Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues”. J. Histochem. Cytochem. 39 (9): 1221–6. doi:10.1177/39.9.1918940. PMID 1918940.
- Araki T, Gejyo F, Takagaki K, et al. (1988). “Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens”. Proc. Natl. Acad. Sci. U.S.A. 85 (3): 679–83. doi:10.1073/pnas.85.3.679. PMC 279618. PMID 3422450.
- Shibata S, Miura K (1982). “Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine”. Nephron. 31 (2): 170–6. doi:10.1159/000182638. PMID 6896906.
- Ueyama H, Deng HX, Ohkubo I (1994). “Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein”. Biochemistry. 32 (48): 12968–76. doi:10.1021/bi00211a004. PMID 8241150.
- Freije JP, Fueyo A, UrÃa JA, et al. (1994). “Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes”. Genomics. 18 (3): 575–87. doi:10.1016/S0888-7543(05)80359-3. PMID 8307568.
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sánchez LM, López-OtÃn C, Bjorkman PJ (1997). “Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog”. Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4626–30. doi:10.1073/pnas.94.9.4626. PMC 20774. PMID 9114041.
- Brysk MM, Lei G, Rajaraman S, et al. (1997). “Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia”. In Vivo. 11 (3): 271–4. PMID 9239523.
- Lei G, Arany I, Selvanayagam P, et al. (1997). “Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors”. J. Cell. Biochem. 67 (2): 216–22. doi:10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-#. PMID 9328826.
- Ogikubo O, Maeda T, Yamane T, et al. (1998). “Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives”. Biochem. Biophys. Res. Commun. 252 (1): 257–62. doi:10.1006/bbrc.1998.9614. PMID 9813179.
- Sánchez LM, Chirino AJ, Bjorkman P (1999). “Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules”. Science. 283 (5409): 1914–9. doi:10.1126/science.283.5409.1914. PMID 10206894.
- Lei G, Brysk H, Arany I, et al. (1999). “Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line”. J. Cell. Biochem. 75 (1): 160–9. doi:10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B. PMID 10462714.
- Davidsson P, Nilsson CL (2000). “Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry”. Biochim. Biophys. Acta. 1473 (2–3): 391–9. doi:10.1016/s0304-4165(99)00197-x. PMID 10594376.
- Kennedy MW, Heikema AP, Cooper A, et al. (2001). “Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins”. J. Biol. Chem. 276 (37): 35008–13. doi:10.1074/jbc.C100301200. PMID 11425849.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). “Human chromosome 7: DNA sequence and biology”. Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). “The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- BURGI W, SCHMID K (1998). “Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma”. J. Biol. Chem. 236: 1066–74. PMID 13689030.