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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Abetimus

Introduction

Abetimus is an immunosuppressant.[1] It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies.[2] It may also complex anti dsDNA antibodies together, therefore disabling them. This way Abetimus is supposed to help treat Systemic Lupus Erythematosus and specifically nephritis.

References

  1. ↑ (not listed) (2003). “Abetimus: Abetimus sodium, LJP 394”. BioDrugs. Adis. 17 (3): 212&ndash, 215. doi:10.2165/00063030-200317030-00009. ISSN 1173-8804. PMID 12749759.
  2. ↑ Wallace, Daniel J. (January 2001), “Clinical and pharmacological experience with LJP-394”, Expert Opinion on Investigational Drugs, Informa, 10 (1), pp. 111&ndash, 117, doi:10.1517/13543784.10.1.111, ISSN 1354-3784, PMID 11116284, retrieved 2 April 2011

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