Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Acenocoumarol
Introduction
Overview
Overview
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.
Dosage
Dosage
Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the correct dosage. Acenocoumarol is contraindicated during pregnancy.
External links
External links
- Template:DiseasesDB
- Cesar J, GarcÃa-Avello A, Navarro J, Herraez M (2004). “Aging and oral anticoagulant therapy using acenocoumarol”. Blood Coagul Fibrinolysis. 15 (8): 673&ndash, 6. doi:10.1097/00001721-200412000-00007. PMIDÂ 15613922.
- Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). “Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?”. Orv Hetil. 145 (52): 2619&ndash, 21. PMID 15724697.
- Ufer M (2005). “Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol”. Clin Pharmacokinet. 44 (12): 1227&ndash, 46. doi:10.2165/00003088-200544120-00003. PMIDÂ 16372822.
- Montes R, Ruiz de Gaona E, MartÃnez-González M, Alberca I, Hermida J (2006). “The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients”. Br J Haematol. 133 (2): 183&ndash, 7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]