Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Acid lipase
Introduction
Lysosomal lipase is a form of lipase which functions intracellularly, in the lysosomes.
Clinical significance
Clinical significance
A deficiency associated with lysosomal acid lipase deficiency, Wolman disease, and cholesteryl ester storage disease.
Chlorpromazine is an inhibitor of lysosomal lipase.[1]
A genome wide survey suggests that lysosomal lipase A (located at chromosome 10q23.31) is associated with coronary artery disease in humans.[2]
References
References
- ↑ Sauro VS, Klamut HJ, Lin CH, Strickland KP (1985). “Lysosomal triacylglycerol lipase activity in L6 myoblasts and its changes on differentiation”. Biochem. J. 227 (2): 583–9. PMC 1144878. PMID 4004781.
- ↑ Wild PS, Zeller T, Schillert A, et al. (May 2011). “A Genome-wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease”. Circ Cardiovasc Genet. 4 (4): 403–12. doi:10.1161/CIRCGENETICS.110.958728. PMC 3157552. PMID 21606135.
External links
External links
- lysosomal+acid+lipase,+human at the US National Library of Medicine Medical Subject Headings (MeSH)