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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Acridine carboxamide

Introduction

Overview

Overview

Acridine carboxamide (N-[(2′-dimethylamino)ethyl]acridine-4-carboxamide) is an chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors.

While the agent was well-tolerated in Phase II clinical trials, it did not show efficacy when tested against various types of cancers.[1][2][3][4]

References

References

  1. ↑ Dittrich C, Dieras V, Kerbrat P; et al. (2003). “Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer”. Investigational new drugs. 21 (3): 347–52. PMID 14578683.
  2. ↑ Caponigro F, Dittrich C, Sorensen JB; et al. (2002). “Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer”. Eur. J. Cancer. 38 (1): 70–4. PMID 11750842.
  3. ↑ Twelves C, Campone M, Coudert B; et al. (2002). “Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme”. Ann. Oncol. 13 (5): 777–80. PMID 12075748.
  4. ↑ Dittrich C, Coudert B, Paz-Ares L; et al. (2003). “Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer”. Eur. J. Cancer. 39 (3): 330–4. PMID 12565985.