Acute promyelocytic leukemia other diagnostic studies

There is no significant role for other diagnostic studies in acute promyelocytic leukemia. However, lumbar puncture can be done to assess for central nervous system involvement.

• Lumber puncture:
  • Assessment of the cerebrospinal fluid (CSF) can be done via lumbar puncture. This diagnostic study is especially useful for patients with acute promyelocytic leukemia who have neurologic deficits, as this is concerning for central nervous system involvement. The cell count from the cerebrospinal fluid will show malignant myeloid cells (typically greater than 2 cells per microliter of cerebrospinal fluid). Treatment of cerebrospinal fluid involvement includes methotrexate, hydrocortisone, and cytarabine.^[1]

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