Health Dictionary
Reliable, easy-to-read patient information on common medical conditions โ written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Acute retinal necrosis risk factors
Introduction
Overview
Overview
The primary risk factors for acute retinal necrosis include immunocompromised status and immunosuppression from disease and prolonged corticosteroid use. Genetic predisposition for certain Caucasian and Japanese populations can increase one’s odds of developing acute retinal necrosis.
Risk Factors
Risk Factors
Risk factors for the development of acute retinal necrosis (ARN) include:[1]
- For Caucasian populations: possessing the HLA-DQw7, HLA-Bw62, and HLA-DR4 antigens[2]
- For Japanese populations: possessing the HLA-Aw33, HLA-B44, and HLA-DRw6 antigens[3]
- Experiencing encephalitis from herpes simplex virus[4]
- Immunocompromised status from prior or concurrent disease[5]
- Immunosuppresion from extended corticosteroid therapy[6]
References
References
- โ Chun HL, Missotten T, Salzmann J, Lightman SL (2007). “Acute Retinal Necrosis: Features, Management, and Outcomes”. Opthalmology. 114: 756โ762. Unknown parameter
|Issue=ignored (|issue=suggested) (help) - โ Holland GN, Cornell PJ, Park MS, Barbetti A, Yuge J, Kreiger AE, Kaplan HJ, Pepose JS, Heckenlively JR, Culbertson WW (1989). “An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62, DR4”. Am. J. Ophthalmol. 108 (4): 370โ4. PMIDย 2801857.
- โ Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoล J, Kฤcik D (2014). “Clinical manifestation of self-limiting acute retinal necrosis”. Med. Sci. Monit. 20: 2088โ96. doi:10.12659/MSM.890469. PMCย 4226315. PMIDย 25356955.
- โ Vandercam T, Hintzen RQ, de Boer JH, Van der Lelij A (2008). “Herpetic encephalitis is a risk factor for retinal necrosis”. Neurology. 71 (16): 1268โ74. doi:10.1212/01.wnl.0000327615.99124.99. PMIDย 18852442.
- โ Moutschen MP, Scheen AJ, Lefebvre PJ (1992). “Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections”. Diabete Metab. 18 (3): 187โ201. PMIDย 1397473.
- โ Yamamoto JH, Boletti DI, Nakashima Y, Hirata CE, Olivalves E, Shinzato MM, Okay TS, Santo RM, Duarte MI, Kalil J (2003). “Severe bilateral necrotising retinitis caused by Toxoplasma gondii in a patient with systemic lupus erythematosus and diabetes mellitus”. Br J Ophthalmol. 87 (5): 651โ2. PMCย 1771672. PMIDย 12714420.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.