Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Acute urate nephropathy
Introduction
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Synonyms and keywords: Acute urate nephropathy
Overview
Overview
Acute uric acid nephropathy (AUAN) is a rapidly progressive reduction in kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine[1][2].
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
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Classification
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Pathophysiology
Overview
Pathophysiology
Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute renal failure.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Causes
Overview
Causes
Acute uric acid nephropathy is usually seen as part of the tumor lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis.
Acute uric acid nephropathy can also be caused by an acute attack of gout.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating Acute uric acid nephropathy from other Diseases
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Epidemiology and Demographics
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Risk Factors
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Screening
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Natural History, Complications and Prognosis
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Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | KUB X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]