Acute uric acid nephropathy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Acute urate nephropathy
Overview
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acute uric acid nephropathy (AUAN) is a rapidly progressive reduction in kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine[1][2].
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Historical Perspective
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Classification
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Pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute renal failure.
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Causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Acute uric acid nephropathy is usually seen as part of the tumor lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis.
Acute uric acid nephropathy can also be caused by an acute attack of gout.
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Differentiating Acute uric acid nephropathy from other Diseases
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Epidemiology and Demographics
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Risk Factors
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Screening
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Natural History, Complications and Prognosis
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Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | KUB X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
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