Adenocarcinoma of the lung causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Genetic mutations are primarily responsible for the development of adenocarcinoma of the lung. Genetic mutations of EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma.

Causes

Genes involved in the pathogenesis of adenocarcinoma of the lung include:^[1]^[2]^[3]^[4]

EGFR (7p11)
KRAS (12p12)
BRAF (7q34)
PIK3CA (3q26)
ERBB2 (17q12)
Translocation EML4/ALK
Tyrosine kinase fusions
ALK (2p23), ROS1 (6q22), and RET (10q11)

References

↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
↑ Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). “Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer”. Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.
↑ Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM; et al. (2012). “Identifying and targeting ROS1 gene fusions in non-small cell lung cancer”. Clin Cancer Res. 18 (17): 4570–9. doi:10.1158/1078-0432.CCR-12-0550. PMC 3703205. PMID 22919003.

Template:WikiDoc Sources

[1] Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.

[2] Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.

[pmid17625570-3] Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). “Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer”. Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.

[pmid22919003-4] Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM; et al. (2012). “Identifying and targeting ROS1 gene fusions in non-small cell lung cancer”. Clin Cancer Res. 18 (17): 4570–9. doi:10.1158/1078-0432.CCR-12-0550. PMC 3703205. PMID 22919003.

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Adenocarcinoma of the lung causes

Overview

Causes

References

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