Health Dictionary Find a Doctor

Adenosylhomocysteinase

Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-homocysteine + H2O ⇌ Lhomocysteine + adenosine

The enzyme contains one tightly bound NAD+ per subunit.

References

References

  1. De La Haba G, Cantoni GL (March 1959). “The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine”. The Journal of Biological Chemistry. 234 (3): 603–8. PMID 13641268.
  2. Palmer JL, Abeles RH (February 1979). “The mechanism of action of S-adenosylhomocysteinase”. The Journal of Biological Chemistry. 254 (4): 1217–26. PMID 762125.
External links

Looking for the patient version?

Back to the patient-friendly article

© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH