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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Adenosylhomocysteinase

Introduction

Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-homocysteine + H2O ⇌ L–homocysteine + adenosine

The enzyme contains one tightly bound NAD+ per subunit.

References

References

  1. ↑ De La Haba G, Cantoni GL (March 1959). “The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine”. The Journal of Biological Chemistry. 234 (3): 603–8. PMID 13641268.
  2. ↑ Palmer JL, Abeles RH (February 1979). “The mechanism of action of S-adenosylhomocysteinase”. The Journal of Biological Chemistry. 254 (4): 1217–26. PMID 762125.
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