Common risk factors in the development of adiposogenital dystrophy are male sex, hypothalamic tumors, infectious, autoimmune, chemical, traumatic, and radiation insults to the brain.

Risk factors for adiposogenital genital dystrophy include:

• Tumors of the hypothalamus and pituitary^[1]
• Male sex ^[2]
• Radiation ^{[3] [4]}
• Autoimmune disease ^{[5] [6]}
• Traumatic brain injuries ^{[7] [8]}
• Infections^{[9] [10]}
• Chemotherapy ^{[11] [12]}
• Deep brain stimulation ^{[13] [14]}