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Adrenoleukodystrophy other imaging findings
Introduction
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Overview
Overview
Proton Magnetic Resonance Spectroscopic (MRS) imaging and Diffusion Tensor Imaging (DTI) may be helpful in the diagnosis of adrenoleukodystrophy
Other Imaging Findings
Other Imaging Findings
Proton Magnetic Resonance Spectroscopic (MRS) imaging and Diffusion Tensor Imaging (DTI) may be helpful in the diagnosis of adrenoleukodystrophy.
- These imaging techniques show changes in metabolic rates and water diffusion parameters. MRS imaging was able to demonstrate low NAA and high choline levels in white matter as a first indicator of metabolic dysfunction, prior to MRI changes in ALD. [1]
- High directionality and structure of white matter, resulting from the directional morphology of myelinated axons, is quantified by a higher relative Fractional anisotropic (FA) with DTI.[2] A decreased FA can be seen in central cALD lesion areas.[1]
References
References
- ↑ 1.0 1.1 Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW; et al. (2003). “Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease”. AJNR Am J Neuroradiol. 24 (8): 1683–9. PMID 13679292.
- ↑ Turk, Bela R.; Moser, Ann B.; Fatemi, Ali (2017). “Therapeutic strategies in adrenoleukodystrophy”. Wiener Medizinische Wochenschrift. 167 (9–10): 219–226. doi:10.1007/s10354-016-0534-2. ISSN 0043-5341.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: