Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Adult-onset Still's disease laboratory findings
Introduction
Overview
Overview
Adult-onset Still’s disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, inflammatory marker such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. Complete blood count may show leukocytosis with a left shift (increased neutrophils), anemia, thrombocytosis or pancytopenia (in cases of hemophagocytic syndrome).
Laboratory Findings
Laboratory Findings
Adult-onset Still’s disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, the following laboratory abnormalities may be observed:
Inflammatory markers
- Increased ferritin (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml)
- Elevated ESR
- Elevated CRP
Complete blood count
- Leukocytosis with pre-dominant neutrophils (left shift)
- Anemia
- Thrombocytosis
- Pancytopenia (in case of hemophagocytic syndrome)
Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT)
- Increased in case of disseminated intravascular coagulation (DIC)
Liver function tests (LFTs)
- Increased lactic dehydrogenase
- Increased aspartate aminotransferase (AST), and alanine aminotransferase (ALT)
- Increased γ‐glutamyltransferase
- Increased bilirubin
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]