Adult T-cell leukemia future or investigational therapies

Molecular targeting therapy like targeting therapy against NOTCH1/FBXW7 mutations, JAK-STAT signaling pathway and inhibition of the PI3K-signaling pathway are the future investigation therapy for adult t-cell leukemia.^[1]^[2]^[3]

↑ Litzow MR, Ferrando AA (August 2015). “How I treat T-cell acute lymphoblastic leukemia in adults”. Blood. 126 (7): 833–41. doi:10.1182/blood-2014-10-551895. PMID 25966987.
↑ Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J (November 2014). “JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model”. Blood. 124 (20): 3092–100. doi:10.1182/blood-2014-04-566687. PMID 25193870.
↑ Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG (April 2012). “Targeting nonclassical oncogenes for therapy in T-ALL”. Cancer Cell. 21 (4): 459–72. doi:10.1016/j.ccr.2012.02.029. PMID 22516257.

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[pmid25966987-1] Litzow MR, Ferrando AA (August 2015). “How I treat T-cell acute lymphoblastic leukemia in adults”. Blood. 126 (7): 833–41. doi:10.1182/blood-2014-10-551895. PMID 25966987.

[pmid25193870-2] Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J (November 2014). “JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model”. Blood. 124 (20): 3092–100. doi:10.1182/blood-2014-04-566687. PMID 25193870.

[pmid22516257-3] Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG (April 2012). “Targeting nonclassical oncogenes for therapy in T-ALL”. Cancer Cell. 21 (4): 459–72. doi:10.1016/j.ccr.2012.02.029. PMID 22516257.

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Adult T-cell leukemia future or investigational therapies

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