Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Alcohol dehydrogenase, iron containing 1
Introduction
Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.[1]
Function
Function
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.[2]
References
References
- ↑ “Entrez Gene: Alcohol dehydrogenase, iron containing 1”. Retrieved 2017-06-16.
- ↑ Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). “Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate”. FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID 16616524.
Further reading
Further reading
- Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (October 2002). “Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)”. DNA Sequence. 13 (5): 301–6. doi:10.1080/1042517021000011636. PMID 12592711.
- Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (March 2009). “Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1”. Chemico-Biological Interactions. 178 (1–3): 283–7. doi:10.1016/j.cbi.2008.10.025. PMID 19013439.
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O’Brien SJ (September 2010). “Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression”. PLoS One. 5 (9): e12862. Bibcode:2010PLoSO…512862H. doi:10.1371/journal.pone.0012862. PMCÂ 2943476. PMIDÂ 20877624.
- Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (March 2013). “Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation”. BMC Cancer. 13: 142. doi:10.1186/1471-2407-13-142. PMCÂ 3618294. PMIDÂ 23517143.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.