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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Amanullin

Introduction

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Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral Template:LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.

Toxicology

Toxicology

Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

References

References

  1. ↑ Cochet-Meilhac M, Chambon P (1974). “Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins”. Biochim. Biophys. Acta. 353 (2): 160–84. PMID 4601749. Unknown parameter |month= ignored (help)
See also

See also

External links