Fetal methotrexate syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]

Synonyms and keywords: Aminopterin embryopathy syndrome, aminopterin fetopathy syndrome, aminopterin syndrome, aminopterin fetopathy

Overview

Congenital abnormalities have been documented with methotrexate and aminopterin, and collectively their teratogenic effects have become known as the fetal aminopterin syndrome.

Diagnosis

History

A directed history should be obtained to ascertain prenatal exposure of methotrexate and aminopterin.

Physical Examination

Head

Craniosynostosis – some or all of the sutures in the skull of an infant or child close too early, causing problems with normal brain and skull growth.

Ear

Low-set ears

Extremities

Neurologic

Developmental delay

References

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