Amyotrophic lateral sclerosis causes

Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS.

Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include:

• Chromosome 9 Open Reading Frame 72(c9orf72)
• TAR DNA-binding protein 43 (TDP-43)
• Fused in Sarcoma (FUS)
• Superoxide Dismutase 1 (SOD1)
• TANK-binding kinase 1 (TBK1)
• Optineurin (OPTN)

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