Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Amyotrophic lateral sclerosis causes
Introduction
Overview
Overview
Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS.
Cause
Cause
Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include:
- Chromosome 9 Open Reading Frame 72(c9orf72)
- TAR DNA-binding protein 43 (TDP-43)
- Fused in Sarcoma (FUS)
- Superoxide Dismutase 1 (SOD1)
- TANK-binding kinase 1 (TBK1)
- Optineurin (OPTN)
References
References
- ↑ Källstig E, McCabe BD, Schneider BL (2021). “The Links between ALS and NF-κB”. Int J Mol Sci. 22 (8). doi:10.3390/ijms22083875. PMC 8070122 Check
|pmc=value (help). PMIDÂ 33918092 PMID: 33918092 Check|pmid=value (help).
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]