Analgesic nephropathy history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD [2]

Overview

Common findings in patients with analgesic nephropathy include: headache, upper gastrointestinal disease (such as peptic ulcer), anemia, urinary tract infections, pyuria and hypertension.

History and Symptoms

History, symptoms and and clinical findings in patients with analgesic nephropathy includes:^[1]^[2]

Headache
Upper gastrointestinal disease (such as peptic ulcer)
Anemia (60%)
Psychiatric disorder
Urinary tract infections (15-60%)
Sterile pyuria (95%)
Hypertension (15-70%)
Tubular epithelial celluria
Microscopic hematuria (35%)
Significant proteinuria (greater than 0.3 gr daily) (40%)
Transitional cell tumours of the urothelium (in abuse of analgesics containing phenacetin)
Varying degrees of renal failure (over 85%)
Clinical gout (5%)
Acidosis
Passage of papillae
Flank or abdominal pain

References

↑ Nanra RS (1980). “Clinical and pathological aspects of analgesic nephropathy”. Br J Clin Pharmacol. 10 Suppl 2: 359S–368S. doi:10.1111/j.1365-2125.1980.tb01824.x. PMC 1430193. PMID 7002190.
↑ Nanra RS, Stuart-Taylor J, de Leon AH, White KH (1978). “Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia”. Kidney Int. 13 (1): 79–92. PMID 362034. Unknown parameter |month= ignored (help)

Overview