Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Anaphylaxis overview
Introduction
Overview
Overview
Anaphylaxis is an acute systemic Type I Hypersensitivity allergic reaction. Anaphylaxis occurs when a person is exposed to a trigger allergen that they have been previously sensitized to. Anaphylaxis can occur through ingestion, skin contact or injection. [1] The allergen causes a release of mast cells into the circulation. [2] It is marked by life threatening compromise of airway, breathing and circulation. [3] Common causes in children are usually food whereas in adults it is usually linked to medications and insect stings. [4] The mainstay of prevention is to avoid the allergen. [1] The mainstay of treatment is epinephrine. [5]
References
References
- ↑ 1.0 1.1 LoVerde D, Iweala OI, Eginli A, Krishnaswamy G (2018). “Anaphylaxis”. Chest. 153 (2): 528–543. doi:10.1016/j.chest.2017.07.033. PMC 6026262. PMID 28800865.
- ↑ Yu JE, Lin RY (2018). “The Epidemiology of Anaphylaxis”. Clin Rev Allergy Immunol. 54 (3): 366–374. doi:10.1007/s12016-015-8503-x. PMID 26357949.
- ↑ Reber LL, Hernandez JD, Galli SJ (2017). “The pathophysiology of anaphylaxis”. J Allergy Clin Immunol. 140 (2): 335–348. doi:10.1016/j.jaci.2017.06.003. PMC 5657389. PMID 28780941.
- ↑ Commins SP (2017). “Outpatient Emergencies: Anaphylaxis”. Med Clin North Am. 101 (3): 521–536. doi:10.1016/j.mcna.2016.12.003. PMC 5381731. PMID 28372711.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). “Digitoxin metabolism by rat liver microsomes”. Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1542/peds.2016-4006 DOI: 10.1542/peds.2016-4006 Check
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD