Anaplastic large cell lymphoma historical perspective

Anaplastic lymphoma was first described by Stien et al in 1985. In 2008, the World Health Organization (WHO) added anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma and anaplastic lymphoma kinase positive large B-cell lymphoma as transitional bodies in the peripheral T-cell lymphoma classification.^[1][2]

• Anaplastic large cell lymphoma was first described by Stein et al in 1985, whom described it as neoplastic proliferation of lymphoid cells which appears anaplastic. When tumor cells always showed labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen.^[3]
• In 1988, ALCL was added to the revised Kiel classification.
• In 1994, it was included in the Revised European-American Lymphoma (REAL) classification.^[3]
• Then in 1997, Delsol discovered anaplastic lymphoma kinase-(ALK-) positive large B-cell lymphoma (ALK+ LBCL).
• In 2008, the World Health Organization (WHO) added anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma and anaplastic lymphoma kinase positive large B-cell lymphoma as provisional entities in the peripheral T-cell lymphoma classification.^[1][2]

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