Anaplastic large cell lymphoma physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]

Overview

Common physical examination findings of anaplastic large cell lymphoma include fever, rash, ulcer, splenomegaly, hepatomegaly, chest tenderness, abdomen tenderness, bone tenderness, peripheral lymphadenopathy, and central lymphadenopathy.

Temperature

Fever is often present^[1]^[2]

Skin

Rash ^[3]
Ulcer

Neck

Cervical lymphadenopathy^[4]

Thorax

Thoracic masses suggestive of central lymphadenopathy^[4]
Chest tenderness^[5]

Abdomen

Abdominal masses suggestive of central lymphadenopathy
Splenomegaly^[1]
Hepatomegaly ^[6]
Abdomen tenderness ^[5]

Extremities

Peripheral lymphadenopathy
Bone tenderness^[7]

References

↑ ^1.0 ^1.1 de Campos FPF, Zerbini MCN, Felipe-Silva A, Simões AB, Lovisolo SM, da Fonseca LG; et al. (2014). “Unusual clinical presentation of anaplastic large cell lymphoma”. Autops Case Rep. 4 (1): 21–27. doi:10.4322/acr.2014.004. PMC 5470561. PMID 28652989.
↑ Al-Ahmad, Selma; Maertens, Vincent; Libeer, Christophe; Schelfhout, Vera; Vanhoenacker, Filip; Boeckx, Nancy; Vandevenne, Marleen (2017). “The masquerading presentation of a systemic anaplastic large cell lymphoma, ALK positive: a case report and review of the literature”. Acta Clinica Belgica. 72 (6): 454–460. doi:10.1080/17843286.2017.1312057. ISSN 1784-3286.
↑ Tagami T, Alhalabi O, Ward N, Huang J (2016). “Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review”. Dermatopathology (Basel). 3 (2): 39–43. doi:10.1159/000445766. PMC 4965535. PMID 27504444.
↑ ^4.0 ^4.1 Yang W, Zuo Y, Yang Y, Tao J, Hong J, Wu Z; et al. (2015). “Pediatric anaplastic large cell lymphoma misdiagnosed as multiple organ abscesses: a case report and literature review”. Int J Clin Exp Med. 8 (10): 19509–16. PMC 4694502. PMID 26770602.
↑ ^5.0 ^5.1 Song HH, Baik GH, Kwon JH, Lee KS, Choi YH, Choi KC; et al. (2005). “A case of primary gastric CD30-positive anaplastic large-cell lymphoma”. J Korean Med Sci. 20 (6): 1062–5. doi:10.3346/jkms.2005.20.6.1062. PMC 2779310. PMID 16361823.
↑ Jiménez Fuertes M, Costa Navarro D, Montalvá Orón EM, López-Andújar R, de Juan Burgueño M, Mir Pallardó J (2013). “Primary hepatic anaplastic large cell ki-1 lymphoma and celiac disease: a casual association?”. J Gastrointest Oncol. 4 (1): 109–13. doi:10.3978/j.issn.2078-6891.2012.059. PMC 3562637. PMID 23451333.
↑ Kim KH, Jung YH, Han CW, Woo IS, Son JH (2016). “A case of Primary Bone Anaplastic Large Cell Lymphoma”. Am J Case Rep. 17: 734–738. PMC 5063430. PMID 27729639.

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[pmid28652989-1] 1.0 ^1.1 de Campos FPF, Zerbini MCN, Felipe-Silva A, Simões AB, Lovisolo SM, da Fonseca LG; et al. (2014). “Unusual clinical presentation of anaplastic large cell lymphoma”. Autops Case Rep. 4 (1): 21–27. doi:10.4322/acr.2014.004. PMC 5470561. PMID 28652989.

[Al-AhmadMaertens2017-2] Al-Ahmad, Selma; Maertens, Vincent; Libeer, Christophe; Schelfhout, Vera; Vanhoenacker, Filip; Boeckx, Nancy; Vandevenne, Marleen (2017). “The masquerading presentation of a systemic anaplastic large cell lymphoma, ALK positive: a case report and review of the literature”. Acta Clinica Belgica. 72 (6): 454–460. doi:10.1080/17843286.2017.1312057. ISSN 1784-3286.

[pmid27504444-3] Tagami T, Alhalabi O, Ward N, Huang J (2016). “Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review”. Dermatopathology (Basel). 3 (2): 39–43. doi:10.1159/000445766. PMC 4965535. PMID 27504444.

[pmid26770602-4] 4.0 ^4.1 Yang W, Zuo Y, Yang Y, Tao J, Hong J, Wu Z; et al. (2015). “Pediatric anaplastic large cell lymphoma misdiagnosed as multiple organ abscesses: a case report and literature review”. Int J Clin Exp Med. 8 (10): 19509–16. PMC 4694502. PMID 26770602.

[pmid16361823-5] 5.0 ^5.1 Song HH, Baik GH, Kwon JH, Lee KS, Choi YH, Choi KC; et al. (2005). “A case of primary gastric CD30-positive anaplastic large-cell lymphoma”. J Korean Med Sci. 20 (6): 1062–5. doi:10.3346/jkms.2005.20.6.1062. PMC 2779310. PMID 16361823.

[pmid23451333-6] Jiménez Fuertes M, Costa Navarro D, Montalvá Orón EM, López-Andújar R, de Juan Burgueño M, Mir Pallardó J (2013). “Primary hepatic anaplastic large cell ki-1 lymphoma and celiac disease: a casual association?”. J Gastrointest Oncol. 4 (1): 109–13. doi:10.3978/j.issn.2078-6891.2012.059. PMC 3562637. PMID 23451333.

[pmid27729639-7] Kim KH, Jung YH, Han CW, Woo IS, Son JH (2016). “A case of Primary Bone Anaplastic Large Cell Lymphoma”. Am J Case Rep. 17: 734–738. PMC 5063430. PMID 27729639.

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