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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Anemia with extrinsic hemolysis

Introduction

Overview

Overview

Differentiating Anemia with extrinsic hemolysis from Other Diseases

Differentiating Anemia with extrinsic hemolysis from Other Diseases

To review the differential diagnosis of anemia, click here.

Disease Genetics Clinical manifestation Lab findings
History Symptoms Signs Hemolysis Intrinsic/Extrinsic Hb concentration MCV RDW Reticulocytosis Haptoglobin levels Hepcidin Iron studies Specific finding on blood smear
Serum iron Serum Tfr level Transferrin or TIBC Ferritin Transferrin saturation
Microangiopathic hemolytic anemia[1][2] − Associated with + Extrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↓ Nl − ↑ −
  • Helmet cells
Macroangiopathic hemolytic anemia[3] Associated with + Extrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↓ Nl − − −
Autoimmune hemolytic anemia[4] − Associated with:
  • Painful, blue fingers and toes with cold weather
 + Extrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↓ Nl − − −
  • RBC agglutination
Infections[5] − Associated with + Extrinsic Normochromic Normocytic ↑ ↑ ↓ Nl Nl Nl − − −
Disease Genetics History Symptoms Signs Hemolysis Intrinsic/Extrinsic Hb concentration MCV RDW Reticulocytosis Haptoglobin levels Hepcidin Serum iron Serum Tfr level IBC Ferritin Transferrin saturation Specific finding on blood smear
References

References

  1. ↑ Morishita E (July 2015). “[Diagnosis and treatment of microangiopathic hemolytic anemia]”. Rinsho Ketsueki (in Japanese). 56 (7): 795–806. doi:10.11406/rinketsu.56.795. PMID 26251142.
  2. ↑ George JN, Charania RS (March 2013). “Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia”. Semin. Thromb. Hemost. 39 (2): 153–60. doi:10.1055/s-0032-1333538. PMID 23390027.
  3. ↑ Westphal RG, Azen EA (May 1971). “Macroangiopathic hemolytic anemia due to congenital cardiovascular anomalies”. JAMA. 216 (9): 1477–8. PMID 5108522.
  4. ↑ Hill QA (October 2015). “Autoimmune hemolytic anemia”. Hematology. 20 (9): 553–4. doi:10.1179/1024533215Z.000000000401. PMID 26447931.
  5. ↑ Bustinduy AL, Parraga IM, Thomas CL, Mungai PL, Mutuku F, Muchiri EM, Kitron U, King CH (March 2013). “Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area”. Am. J. Trop. Med. Hyg. 88 (3): 433–40. doi:10.4269/ajtmh.12-0552. PMC 3592521. PMID 23324217.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]