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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Anemia with intrinsic hemolysis

Introduction

Overview

Overview

Differentiating Anemia with intrinsic hemolysis from Other Diseases

Differentiating Anemia with intrinsic hemolysis from Other Diseases

To review the differential diagnosis of anemia, click here.

Disease Genetics Clinical manifestation Lab findings
History Symptoms Signs Hemolysis Intrinsic/Extrinsic Hb concentration MCV RDW Reticulocytosis Haptoglobin levels Hepcidin Iron studies Specific finding on blood smear
Serum iron Serum Tfr level Transferrin or TIBC Ferritin Transferrin saturation
G6pd deficiency[1]
  • History of using
 + Intrinsic Normochromic Normocytic ↑ ↑ but usually causes resolution within 4-7 days ↓ ↓ Nl to ↑ Nl ↑ ↑ ↑
Pyruvate kinase deficiency[2] + Intrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↑ Nl Nl ↑ βˆ’
Sickle cell anemia[3] + Intrinsic Normochromic Normocytic ↑ ↑ ↓ Nl or moderately ↑ Nl Nl Nl or moderately ↑ ↓ Nl
Disease Genetics History Symptoms Signs Hemolysis Intrinsic/Extrinsic Hb concentration MCV RDW Reticulocytosis Haptoglobin levels Hepcidin Serum iron Serum Tfr level IBC Ferritin Transferrin saturation Specific finding on blood smear
HbC disease[4]
  • Glutamic acid–to-lysine mutation in Ξ²-globin
 + Intrinsic Normochromic Normocytic ↑ ↑ ↓ Nl Nl Nl Nl ↓ βˆ’
Paroxysmal nocturnal hemoglobinuria[5][6] + Intrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↓ Nl ↑ ↓ βˆ’ NA
Hereditary spherocytosis[7] + Intrinsic Normochromic Normocytic ↑ ↑ ↓ Nl ↓ Nl ↑ Nl βˆ’
  • Small, round RBCs with less surface area and no central pallor
References

References

  1. ↑ Luzzatto L, Seneca E (February 2014). “G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications”. Br. J. Haematol. 164 (4): 469–80. doi:10.1111/bjh.12665. PMCΒ 4153881. PMIDΒ 24372186.
  2. ↑ Grace RF, Zanella A, Neufeld EJ, Morton DH, Eber S, Yaish H, Glader B (September 2015). “Erythrocyte pyruvate kinase deficiency: 2015 status report”. Am. J. Hematol. 90 (9): 825–30. doi:10.1002/ajh.24088. PMCΒ 5053227. PMIDΒ 26087744.
  3. ↑ Singh PC, Ballas SK (March 2015). “Emerging drugs for sickle cell anemia”. Expert Opin Emerg Drugs. 20 (1): 47–61. doi:10.1517/14728214.2015.985587. PMIDΒ 25431087.
  4. ↑ Lemonne N, Billaud M, Waltz X, Romana M, Hierso R, Etienne-Julan M, Connes P (2016). “Rheology of red blood cells in patients with HbC disease”. Clin. Hemorheol. Microcirc. 61 (4): 571–7. doi:10.3233/CH-141906. PMIDΒ 25335812.
  5. ↑ Bunyaratvej A, Butthep P (January 1992). “Cytometric analysis of paroxysmal nocturnal hemoglobinuria erythrocytes”. J Med Assoc Thai. 75 Suppl 1: 237–42. PMIDΒ 1402472.
  6. ↑ Kahng J, Kim Y, Kim JO, Koh K, Lee JW, Han K (January 2015). “A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data”. Ann Lab Med. 35 (1): 35–40. doi:10.3343/alm.2015.35.1.35. PMCΒ 4272963. PMIDΒ 25553278.
  7. ↑ Da Costa L, Galimand J, Fenneteau O, Mohandas N (July 2013). “Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders”. Blood Rev. 27 (4): 167–78. doi:10.1016/j.blre.2013.04.003. PMIDΒ 23664421.

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