Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Ankyrins
Introduction
Overview
Overview
Ankyrins are a family of proteins that mediates the attachment of integral membrane proteins to the cytoskeleton.[1]
Ankyrin 1, was first discovered in the erythrocytes but also later found to be expressed in the brain and muscles. In erythrocytes, Ankyrin 1 links membrane receptor CD44 to inositol triphosphate and the cytoskeleton.[2]
Ankyrin contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD) consisting of 22–24 tandem repeats of 33 amino acids, a spectrin binding domain and a variably sized C-terminal regulatory domain.
Ankyrin was discovered by Dr. G. Vann Bennett (M.D., PhD.) in 1976.
References
References
- ↑ Hryniewicz-Jankowska A, Czogalla A, Bok E, Sikorsk AF (2002). “Ankyrins, multifunctional proteins involved in many cellular pathways”. Folia Histochem Cytobiol. 40 (3): 239–49. PMID 12219834.
- ↑ Singleton PA, Bourguignon LY (2004). “CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation”. Exp Cell Res. 295 (1): 102–18. PMID 15051494.
External links
External links
- Ankyrins at the US National Library of Medicine Medical Subject Headings (MeSH)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Cafer Zorkun, M.D., Ph.D. [2]