Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Aphidicolin
Introduction
Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties.
Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S-phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an Apoptosis inducer in HeLa cells.
Further reading
Further reading
Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients