Aplastic anemia causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]
Overview
Overview
Common causes of aplastic anemia include hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV. Medicines, such as Albendazole, Cefadroxil, Chlorpromazine, chloramphenicol , Carbamazepine, Hydroxychloroquine, Methimazole, Orphenadrine, Oxcarbazepine, Phenytoin, Quinine, Phenylbutazone, Sulindac, Sulfadiazine, Sulfasalazine, Valganciclovir hydrochloride. Other causes include radiation, chemotherapy, toxins, such as pesticides, arsenic, and benzene, and metastasis to bone marrow. Less common causes of aplastic anemia are Lupus (SLE), rheumatoid arthritis, .pregnancy, Thymoma, and collagen vascular disease.
Causes
Causes
Life-threatening Causes[edit | edit source]
- There are no life-threatening causes of aplastic anemia.
Common Causes
Common causes of aplastic anemia may include:[1]
- Idiopathic
- Infectious diseases, such as hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV.
- Medicines, such as Albendazole, Cefadroxil, Chlorpromazine, chloramphenicol , Carbamazepine, Hydroxychloroquine, Methimazole, Orphenadrine, Oxcarbazepine, Phenytoin, Quinine, Phenylbutazone, Sulindac, Sulfadiazine, Sulfasalazine, Valganciclovir hydrochloride.
- Radiation
- chemotherapy
- Toxins, such as pesticides, arsenic, and benzene
- Metastasis
Less Common Causes
Less common causes of aplastic anemia include:[1]
- Pregnancy
- Thymoma
- Collagen vascular disease
Genetic Causes
Certain genetic conditions can damage the stem cells and lead to aplastic anemia:[2]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Albendazole, Cefadroxil, Chlorpromazine, chloramphenicol , Carbamazepine, Hydroxychloroquine, Methimazole, Orphenadrine, Oxcarbazepine, Phenytoin, Quinine, Phenylbutazone, Sulindac, Sulfadiazine, Sulfasalazine, Valganciclovir hydrochloride |
| Ear Nose Throat | No underlying causes |
| Endocrine | Thymoma |
| Environmental | No underlying causes |
| Gastroenterologic | Fulminent hepatitis |
| Genetic | Fanconi anemia |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV. |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Severe vit B12 and Folate deficiency |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Acute lymphocytic leukemia, MDS |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | pesticides, arsenic, and benzene |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | SLE, Rheumatoid arthritis |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Anorexia |
Causes in Alphabetical Order
- Autoimmune diseases
- Albendazole
- Arsenic
- Benzene
- Ceftazidime
- Cefaclor
- Cefaclor
- Certolizumab pegol
- Chlorpropamide
- Chloramphenicol sodium succinate
- Dactinomycin
- Dapsone
- Dyskeratosis congenita
- Diamond-Blackfan anemia.
- Eltrombopag
- Fanconi anemia
- Felbamate
- Flurbiprofen
- Flucytosine
- interferon alfacon-1
- Isoniazid
- Lincomycin Hydrochloride
- Meprobamate
- Nilutamide
- Oxaprozin
- Penicillamine
- Probenecid
- pesticides
- Tolbutamide
- Tolazamide
- Sodium aurothiomalate
- Sodium phenylbutyrate
- Sulfamethoxazole/Trimethoprim
- Sulfasalazine
- Sulfacetamide
- Thymoma
References
References
- ↑ 1.0 1.1 Young, Neal S. (2002). “Acquired Aplastic Anemia”. Annals of Internal Medicine. 136 (7): 534. doi:10.7326/0003-4819-136-7-200204020-00011. ISSN 0003-4819.
- ↑ Shallis, Rory M; Ahmad, Rami; Zeidan, Amer M (2018). “Aplastic anemia: etiology, molecular pathogenesis and emerging concepts”. European Journal of Haematology. doi:10.1111/ejh.13153. ISSN 0902-4441.
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