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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Ascofuranone

Introduction

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Ascofuranone is an antibiotic that inhibits the Trypanosoma brucei alternative oxidase and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of sleeping sickness.[1] The compound is effective both in vitro cell culture and in infections in mice.[2]

Ascofuranone has also been reported to have anti-tumor activity,[3] and modulate the immune system.[4]

References

  1. ↑ Minagawa N, Yabu Y, Kita K, Nagai K, Ohta N, Meguro K, Sakajo S, Yoshimoto A (1997). “An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei”. Mol. Biochem. Parasitol. 84 (2): 271–80. PMID 9084049.
  2. ↑ Yabu Y, Yoshida A, Suzuki T, Nihei C, Kawai K, Minagawa N, Hosokawa T, Nagai K, Kita K, Ohta N (2003). “The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice”. Parasitol. Int. 52 (2): 155–64. PMID 12798927.
  3. ↑ Magae J, Hayasaki J, Matsuda Y, Hotta M, Hosokawa T, Suzuki S, Nagai K, Ando K, Tamura G (1988). “Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes”. J. Antibiot. 41 (7): 959–65. PMID 3417568.
  4. ↑ Magae J, Suzuki S, Nagai K, Yamasaki M, Ando K, Tamura G (1986). “In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system”. Cancer Res. 46 (3): 1073–8. PMID 3080231.