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Ascorbate peroxidase
Introduction
Ascorbate peroxidases (or APX) are enzymes that detoxify peroxides such as hydrogen peroxide using ascorbate as a substrate. The reaction they catalyse is the transfer of electrons from ascorbate to a peroxide, producing dehydroascorbate and water as products.[1]
Ascorbate + Hydrogen peroxide → Dehydroascorbate + Water
C6H8O6 + H2O2 → C6H6O6 + 2 H2O
These enzymes are commonly hemoproteins and the haem cofactor is the site of the oxidation-reduction reaction shown above.[2]
References
References
- ↑ Raven EL (2000). “Peroxidase-catalyzed oxidation of ascorbate. Structural, spectroscopic and mechanistic correlations in ascorbate peroxidase”. Subcell. Biochem. 35: 317–49. PMID 11192727.
- ↑ Raven EL, Lad L, Sharp KH, Mewies M, Moody PC (2004). “Defining substrate specificity and catalytic mechanism in ascorbate peroxidase”. Biochem. Soc. Symp. (71): 27–38. PMID 15777010.