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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Asialoglycoprotein receptor

Introduction

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.[1]

References

References

  1. ↑ Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K (December 2012). “Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity”. Auto- Immunity Highlights. 3 (3): 119–25. doi:10.1007/s13317-012-0041-4. PMC 4389076. PMID 26000135.
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