Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Asplenia risk factors
Introduction
Overview
Overview
Common risk factors include: Trauma; atraumatic indication for splenectomy includes: hematological autoimmune disorder, Idiopathic Thrombocytopenic Purpura (ITP), Autoimmune Hemolytic Anemia (AIHA); Surgery includes: unexplained splenomegaly, autoimmune, malignant. Less Common Risk Factors include: mutation in gene RPSA and human genes, connexin 43 and ZIC3.
Risk Factors
Risk Factors
Common Risk Factors
- Common risk factors in the development of asplenia include:
- Trauma [1]
- Atraumatic indication for splenectomy includes:[2]
- Surgery
- Unexplained splenomegaly
- Autoimmune diseases
- Malignancy
Less Common Risk Factors
- Less common risk factor include:
- Mutations in the gene RPSA, is a risk factor for Isolated asplenia.[3]
- Two human genes, connexin 43 and ZIC3, is a risk factor for heterotaxy syndrome.[4]
References
References
- ↑ Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N, Mese T (2015). “Asplenia in children with congenital heart disease as a cause of poor outcome”. Cent Eur J Immunol. 40 (2): 266–9. doi:10.5114/ceji.2015.52841. PMC 4637402. PMID 26557043.
- ↑ Browning MG, Bullen N, Nokes T, Tucker K, Coleman M (2017). “The evolving indications for splenectomy”. Br J Haematol. 177 (2): 321–324. doi:10.1111/bjh.14060. PMID 27018168.
- ↑ Bolze A (2014). “[Connecting isolated congenital asplenia to the ribosome]”. Biol Aujourdhui. 208 (4): 289–98. doi:10.1051/jbio/2015001. PMID 25840456.
- ↑ Ahmed SA, Zengeya S, Kini U, Pollard AJ (2010). “Familial isolated congenital asplenia: case report and literature review”. Eur J Pediatr. 169 (3): 315–8. doi:10.1007/s00431-009-1030-0. PMID 19618213.
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalpana Giri, MBBS[2]