Atherosclerosis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Niloofarsadaat Eshaghhosseiny, MD [2]

Overview

Atherosclerosis may be caused by inflamation,immunity or infection.Atherosclerosis is a disease with multiple genetic and environmental contributions. To review risk factors for the development of atherosclerosis, click here.

Causes

Life-threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.complications resulting from untreated atherosclerosis is common.
Atherosclerosis is a life-threatening cause of acute cronary syndrome and stroke.

Common Causes

Common causes of atherosclerosis may include:

Immunity
Inflamation
Infections,such as geram negative sepsis,can cause type 2 acute cronary syndrome.^[1]
Smoking
HTN
HLP
DM
Kidney disease
Adiposity^[2]

Less Common Causes

Less common causes of [disease name] include:

[Cause1]
[Cause2]
[Cause3]

Genetic Causes

Atherosclerosis can caused by expression in the PCSK9 gene.^[3]
Mutation one of the three genes below can cause familal hypercholesterolemia:LDLR,APOB3,PCSK9.^[4]
In human nearly 40 quantitative trait loci have been found for atherosclerosis.^[5]

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

Cause 1
Cause 2
Cause 3
Cause 4
Cause 5
Cause 6
Cause 7
Cause 8
Cause 9
Cause 10

References

↑ Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V; et al. (2018). “Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week”. J Am Coll Cardiol. 72 (17): 2071–2081. doi:10.1016/j.jacc.2018.08.1043. PMC 6196735. PMID 30336831.
↑ Schmoldt A, Benthe HF, Haberland G (1975). “Digitoxin metabolism by rat liver microsomes”. Biochem Pharmacol. 24 (17): 1639–41. PMID doi.org/10.1161 Check |pmid= value (help).
↑ Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S; et al. (2012). “Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels”. Atherosclerosis. 220 (2): 381–6. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.
↑ Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ; et al. (2015). “Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome”. Eur Heart J. 36 (9): 560–5. doi:10.1093/eurheartj/ehu058. PMID 24585268.
↑ Chen Y, Rollins J, Paigen B, Wang X (2007). “Genetic and genomic insights into the molecular basis of atherosclerosis”. Cell Metab. 6 (3): 164–79. doi:10.1016/j.cmet.2007.07.001. PMC 2083632. PMID 17767904.

Template:WH Template:WS CME Category::Cardiology

[pmid30336831-1] Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V; et al. (2018). “Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week”. J Am Coll Cardiol. 72 (17): 2071–2081. doi:10.1016/j.jacc.2018.08.1043. PMC 6196735. PMID 30336831.

[pmiddoi.org/10.1161-2] Schmoldt A, Benthe HF, Haberland G (1975). “Digitoxin metabolism by rat liver microsomes”. Biochem Pharmacol. 24 (17): 1639–41. PMID doi.org/10.1161 Check |pmid= value (help).

[pmid22176652-3] Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S; et al. (2012). “Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels”. Atherosclerosis. 220 (2): 381–6. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.

[pmid24585268-4] Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ; et al. (2015). “Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome”. Eur Heart J. 36 (9): 560–5. doi:10.1093/eurheartj/ehu058. PMID 24585268.

[pmid17767904-5] Chen Y, Rollins J, Paigen B, Wang X (2007). “Genetic and genomic insights into the molecular basis of atherosclerosis”. Cell Metab. 6 (3): 164–79. doi:10.1016/j.cmet.2007.07.001. PMC 2083632. PMID 17767904.

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