Atovaquone overdosage

There is no known antidote for atovaquone, and it is currently unknown if atovaquone is dialyzable. The median lethal dose is higher than the maximum oral dose tested in mice and rats (1,825 mg/kg/day). Overdoses up to 31,500 mg of atovaquone have been reported. In 1 such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.^[1]

Adapted from the FDA Package Insert.