Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Atypical small acinar proliferation
Introduction
Template:DiseaseDisorder infobox
Steven C. Campbell, M.D., Ph.D.
Overview
Overview
In urologic pathology, atypical small acinar proliferation, abbreviated ASAP, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.
ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty,[1] and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test.
Association with adenocarcinoma
Association with adenocarcinoma
On a subsequent biopsy, given the diagnosis of ASAP, the chance of finding prostate adenocarcinoma is approximately 40%; this is higher than if there is high-grade prostatic intraepithelial neoplasia (HGPIN).[2]
References
References
- ↑ Flury SC, Galgano MT, Mills SE, Smolkin ME, Theodorescu D (2007). “Atypical small acinar proliferation: biopsy artefact or distinct pathological entity”. BJU International. 99 (4): 780–5. Unknown parameter
|month=ignored (help) - ↑ Leite KR, Camara-Lopes LH, Cury J, Dall’oglio MF, Sañudo A, Srougi M (2008). “Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy”. Clinics. 63 (3): 339–42. PMID 18568243. Unknown parameter
|month=ignored (help) - ↑ Bostwick DG, Meiers I (2006). “Atypical small acinar proliferation in the prostate: clinical significance in 2006”. Arch. Pathol. Lab. Med. 130 (7): 952–7. PMID 16831049. Unknown parameter
|month=ignored (help)