Autoimmune lymphoproliferative syndrome causes

The autoimmune lymphoproliferative syndrome is a disease caused by the defect in FAS-mediated apoptosis.

• Most of the cases autosomal dominant, heterozygous germline mutation in FAS. ^[1]
• Somatic FAS mutation is the second most common cause.
• Minority of cases mutations in the genes encoding FAS ligand, caspase 10, caspase 8, and neuroblastoma RAS.
• One-third of patients have unidentified genetic defects.