Autoimmune lymphoproliferative syndrome epidemiology and demographics

Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease that mostly affects children of early age. The incidence and prevalence of ALPS are unknown. Male predominance has been found.

• The incidence of Autoimmune lymphoproliferative syndrome(ALPS) is unknown as many cases remain undiagnosed or misdiagnosed.^[1]

• The prevalence is not known as many cases are left unidentified. A total of 500 patients with ALPS have been identified, from more than 300 families.^[2]

• The mortality rate is 15% in patients with ALPS-FAS by age 50.^[2]

• Patients of all age groups may develop Autoimmune lymphoproliferative syndrome.^[3]
• Typically ALPS appears in early childhood. The median age at diagnosis is 3 years.^[4]

• There is no racial predilection to Autoimmune Lymphoproliferative Syndrome.

• Males are more commonly affected by Autoimmune lymphoproliferative syndrome than females. The male to female ratio is 14:4.^[3]

• There is no information about any specific region where Autoimmune lymphoproliferative syndrome is prevalent.