Autoimmune lymphoproliferative syndrome history and symptoms

Autoimmune lymphoproliferative syndrome (ALPS) hard to diagnose due to expressions of different phenotypes and overlapping symptoms with other hematological disorders. The most common symptoms of ALPS are related to lymphadenopathy predominantly in cervical region, splenomegaly with or without features of hypersplenism or hepatomegaly, and autoimmune cytopenias as thrombocytopenia, hemolytic anemia or occasional neutropenia. Autoimmune cytopenia and lymphoproliferation occur simultaneously in most cases but can also happen separately or in an interval.

Common symptoms include:

• Fatigue^[1]
• Recurrent infections – due to neutropenia^[2]
• Abdominal pain
• Bruising
• Excessive bleeding