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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Autoimmune polyendocrine syndrome classification

Introduction

Overview

Overview

Autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3 on the basis of organ involvement. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. APS type 2 most commonly presents with Addison’s disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 usually presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia.

Classification

Classification

On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3.[1][2][3]

 
 
 
 
 
 
 
 
Autoimmune polyendocrine syndrome (APS)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Autoimmune polyendocrine syndrome type 1
 
 
 
 
Autoimmune polyendocrine syndrome type 2
 
 
 
 
Autoimmune polyendocrine syndrome type 3
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
•Mucocutaneous candidiasis
•Hypoparathyroidism
•Addison’s disease
 
 
 
 
•Addison’s disease
•Autoimmune thyroiditis
•Diabetes mellitus type 1
 
 
 
 
•Autoimmune thyroiditis
•Diabetes mellitus type 1
•Pernicious anemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Autoimmune polyendocrine syndrome type 3A
 
 
 
Autoimmune polyendocrine syndrome type 3B
 
 
 
 
 
Autoimmune polyendocrine syndrome type 3C
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
•Autoimmune thyroiditis
•Immune mediated diabetes mellitus
 
 
 
•Autoimmune thyroiditis
•Pernicious anemia
 
 
 
 
 
•Autoimmune thyroiditis
•Vitiligo/Alopecia
References

References

  1. ↑ Betterle C, Zanchetta R (2003). “Update on autoimmune polyendocrine syndromes (APS)”. Acta Biomed. 74 (1): 9–33. PMID 12817789.
  2. ↑ Forcier RJ, McIntyre OR, Frey WG, Andrada JA, Streiff RR (1972). “Autoimmunity and multiple endocrine abnormalities”. Arch. Intern. Med. 129 (4): 638–41. PMID 5067225.
  3. ↑ Eisenbarth GS, Gottlieb PA (2004). “Autoimmune polyendocrine syndromes”. N. Engl. J. Med. 350 (20): 2068–79. doi:10.1056/NEJMra030158. PMID 15141045.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]