B-cell prolymphocytic leukemia pathophysiology

B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.

• B-cell prolymphocytic leukemia cells are positive for B cell markers such as CD19, CD20, CD22.^[1]
• CD23 is negative but CD5 is expressed in one third tumor cells population.^[2][3]
• Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7^[4]
• Tumor cells express surface IgM proteins.

• The originating cell line for B-cell prolymphocytic leukemia is a mature B-cells and are medium sized cells.
• More than 50 percent of the circulating cells in the peripheral blood are prolymphocytes.
• The nucleus is typically round or oval, and the cytoplasm is usually moderately abundant.
• Leukemic cells can be found in peripheral blood, lymph nodes, bone marrow, spleen, liver, and skin.^[5]

Template:WikiDoc Sources