Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
BCR gene
Introduction
The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.[1]
External links
External links
- BCR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Further reading
Further reading
- Wang L, Seale J, Woodcock BE, Clark RE (2002). “e19a2-positive chronic myeloid leukaemia with BCR exon e16-deleted transcripts”. Leukemia. 16 (8): 1562–3. doi:10.1038/sj.leu.2402600. PMID 12145699.