Health Dictionary
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BIP Trial
Introduction
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Objective
To determine the safety and efficacy of bezafibrate in raising HDL cholesterol and lowering triglycerides in patients with coronary artery disease.
Methods
This is a double-blinded study where 3090 patients with a previous myocardial infarction or stable angina with a total cholesterol of 180 – 250 mg/dL, HDL-C≤45 mg/dL, triglycerides≤300 mg/dL, and low-density lipoprotein cholesterol≤180 mg/dL were randomized to receive either 400 mg of bezafibrate per day or a placebo; they were followed for a mean of 6.2 years. fatal or nonfatal myocardial infarction or sudden death were the primary outcomes considered.
Results
Results
- 18% increase in HDL-C and a 21% reduction observed in triglycerides.
- The reduction in the cumulative probability of the primary end point was 7.3% (P=0.24) after 6.2 years.
- Post hoc analysis in the group of patients with high baseline triglycerides (≥ 200 mg/dL) revealed a reduction by 39.5% (P=0.02) in the cumulative probability of the primary end point.
- Total and noncardiac mortality, adverse events and cancer were equally distributed between the two groups.
Conclusion
Bezafibrate was safe and effective in elevating HDL-C levels and lowering triglycerides. A reduction of the incidence of primary end points was also observed.[1]
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]