BPIFB1
BPI fold containing family B, member 1 is a protein that in humans is encoded by the BPIFB1 gene.[1]
Function
Function
The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008].
Model organisms
Model organisms
Model organisms have been used in the study of BPIFB1 function. A conditional knockout mouse line called Bpifb1tm1e(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[2] Male and female animals underwent a standardized phenotypic screen[3] to determine the effects of deletion.[4][5][6][7] Additional screens performed: – In-depth immunological phenotyping[8] – in-depth bone and cartilage phenotyping[9]
| Characteristic | Phenotype |
|---|---|
| All data available at.[3][8][9] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Insulin | Normal |
| Haematology 6 Weeks | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
References
References
- ↑ “Entrez Gene: BPI fold containing family B, member 1”.
- ↑ Gerdin AK (2010). “The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice”. Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 3.0 3.1 “International Mouse Phenotyping Consortium”.
- ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). “A conditional knockout resource for the genome-wide study of mouse gene function”. Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ↑ Dolgin E (Jun 2011). “Mouse library set to be knockout”. Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ Collins FS, Rossant J, Wurst W (Jan 2007). “A mouse for all reasons”. Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). “Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes”. Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
- ↑ 8.0 8.1 “Infection and Immunity Immunophenotyping (3i) Consortium”.
- ↑ 9.0 9.1 “OBCD Consortium”.
External links
External links
- Human BPIFB1 genome location and BPIFB1 gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Larocque RC, Sabeti P, Duggal P, Chowdhury F, Khan AI, Lebrun LM, Harris JB, Ryan ET, Qadri F, Calderwood SB (Apr 2009). “A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population” (PDF). Genes and Immunity. 10 (3): 267–72. doi:10.1038/gene.2009.2. PMC 2672110. PMID 19212328.
- Zhang B, Nie X, Xiao B, Xiang J, Shen S, Gong J, Zhou M, Zhu S, Zhou J, Qian J, Lu H, He X, Li X, Hu G, Li G (Sep 2003). “Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray”. Genes, Chromosomes & Cancer. 38 (1): 80–90. doi:10.1002/gcc.10247. PMID 12874788.
- Bingle CD, Seal RL, Craven CJ (Aug 2011). “Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily”. Biochemical Society Transactions. 39 (4): 977–83. doi:10.1042/BST0390977. PMC 3196848. PMID 21787333.
- Bingle CD, Craven CJ (Apr 2002). “PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx”. Human Molecular Genetics. 11 (8): 937–43. doi:10.1093/hmg/11.8.937. PMID 11971875.
- Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M, Bingle L (May 2010). “Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts”. Histochemistry and Cell Biology. 133 (5): 505–15. doi:10.1007/s00418-010-0683-0. PMC 2852594. PMID 20237794.
- Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, LeClair EE, Mauad T, Zhou Z, Mall MA, Bingle CD (Nov 2012). “BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease”. Histochemistry and Cell Biology. 138 (5): 749–58. doi:10.1007/s00418-012-0990-8. PMC 3470695. PMID 22767025.
- Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB (Nov 2011). “LPLUNC1 modulates innate immune responses to Vibrio cholerae”. The Journal of Infectious Diseases. 204 (9): 1349–57. doi:10.1093/infdis/jir544. PMC 3182310. PMID 21900486.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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