Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Barrett's esophagus causes
Introduction
Causes
Causes
Barrett’s esophagus is caused by Gastroesophageal reflux disease (GERD). There are several anatomic-pathophysiologic abnormalities that may contribute to GERD:[1][2][3][4][5]
- Hypersecretion of gastric acid
- Decreased concentration of epidermal growth factor in salivary secretions
- Diminished esophageal pain sensitivity
- Poor contraction of the esophagus
- Decreased muscle tone of the lower esophageal sphincter
References
References
- ↑ Spechler SJ. Barrett’s esophagus. Semin Gastrointest Dis 1996; 7:51.
- ↑ Spechler SJ (1996). “Barrett’s esophagus”. Semin Gastrointest Dis. 7 (2): 51–60. PMID 8705259.
- ↑ Lavy UI, Funcke AB, van Hell G, Timmerman H (1973). “Pharmacological properties of ((3alpha-tropanyl)oxy)-5H-benzo(4,5)cycloheptal(1,2-b)-pyridine hydrogen maleate (BS 7723)”. Arzneimittelforschung. 23 (6): 854–8. PMID 4146903.
- ↑ von Schrenck T (2000). “[Diagnosis of gastroesophageal reflux and Barrett esophagus]”. Zentralbl Chir. 125 (5): 414–23. PMID 10929625.
- ↑ Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R; et al. (2017). “Barrett’s metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux”. Am J Physiol Gastrointest Liver Physiol. 312 (6): G615–G622. doi:10.1152/ajpgi.00268.2016. PMID 28336546.
Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]