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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Barrett's esophagus risk factors

Introduction

Overview

Overview

The most potent risk factor in the development of Barrett’s Oesophagus is chronic GERD. Other risk factors include age (>older than 50 years), sex (male), race (caucasian), hiatal hernia, elevated body mass index and intra-abdominal distribution of body fat.

Risk factors

Risk factors

The followings are the risk factors for the Barrett’s esophagus;

Protective factors

Protective factors

References

References

  1. ↑ Cook MB, Wild CP, Forman D (2005). “A systematic review and meta-analysis of the sex ratio for Barrett’s esophagus, erosive reflux disease, and nonerosive reflux disease”. Am J Epidemiol. 162 (11): 1050–61. doi:10.1093/aje/kwi325. PMID 16221805.
  2. ↑ Ek WE, Lagergren K, Cook M, Wu AH, Abnet CC, Levine D; et al. (2016). “Polymorphisms in genes in the androgen pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma”. Int J Cancer. 138 (5): 1146–52. doi:10.1002/ijc.29863. PMC 4715576. PMID 26414697.
  3. ↑ von Schrenck T (2000). “[Diagnosis of gastroesophageal reflux and Barrett esophagus]”. Zentralbl Chir. 125 (5): 414–23. PMID 10929625.
  4. ↑ Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R; et al. (2017). “Barrett’s metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux”. Am J Physiol Gastrointest Liver Physiol. 312 (6): G615–G622. doi:10.1152/ajpgi.00268.2016. PMID 28336546.
  5. ↑ Anderson LA, Watson RG, Murphy SJ, Johnston BT, Comber H, Mc Guigan J; et al. (2007). “Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma: results from the FINBAR study”. World J Gastroenterol. 13 (10): 1585–94. PMC 4146903. PMID 17461453.
  6. ↑ Jacobson BC, Chan AT, Giovannucci EL, Fuchs CS (2009). “Body mass index and Barrett’s oesophagus in women”. Gut. 58 (11): 1460–6. doi:10.1136/gut.2008.174508. PMC 2763036. PMID 19336423.
  7. ↑ Edelstein ZR, Farrow DC, Bronner MP, Rosen SN, Vaughan TL (2007). “Central adiposity and risk of Barrett’s esophagus”. Gastroenterology. 133 (2): 403–11. doi:10.1053/j.gastro.2007.05.026. PMID 17681161.
  8. ↑ Kamat P, Wen S, Morris J, Anandasabapathy S (2009). “Exploring the association between elevated body mass index and Barrett’s esophagus: a systematic review and meta-analysis”. Ann Thorac Surg. 87 (2): 655–62. doi:10.1016/j.athoracsur.2008.08.003. PMID 19161814.
  9. ↑ Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ (2011). “American Gastroenterological Association medical position statement on the management of Barrett’s esophagus”. Gastroenterology. 140 (3): 1084–91. PMID 21376940. Unknown parameter |month= ignored (help)
  10. ↑ Whiteman DC, Kendall BJ (2016). “Barrett’s oesophagus: epidemiology, diagnosis and clinical management”. Med J Aust. 205 (7): 317–24. PMID 27681974.
  11. ↑ Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G (2007). “Relationship between Helicobacter pylori infection and esophageal neoplasia: a meta-analysis”. Clin Gastroenterol Hepatol. 5 (12): 1413–7, 1417.e1–2. doi:10.1016/j.cgh.2007.08.010. PMID 17997357.
  12. ↑ Wang C, Yuan Y, Hunt RH (2009). “Helicobacter pylori infection and Barrett’s esophagus: a systematic review and meta-analysis”. Am J Gastroenterol. 104 (2): 492–500, quiz 491, 501. doi:10.1038/ajg.2008.37. PMID 19174811.

Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]