Blepharitis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2], Sara Mehrsefat, M.D. [3]

Overview

Common causes of blepharitis include bacterial infections, dysfunctional meibomian glands, allergies, and Demodex folliculorum.^[1]^[2]

Causes

Common causes of blepharitis include:^[1]^[2]^[3]^[4]^[5]

Bacterial colonization
- Staphylococcus aureus (most common)
- Corynebacterium
- Staphylococcus epidermidis
Dysfunctional meibomian glands
Allergies
Demodex folliculorum

Blepharitis may be also caused by:^[6]

Lipoid proteinosis (autosomal recessive condition)
Periorbital cellulitis
Dipivefrin

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Chemical irritants, mustard gas
Dental	No underlying causes
Dermatologic	Atopic dermatitis, congenital erythropoietic porphyria, contact dermatitis, dyskeratosis congenita, epidermolysis bullosa, psoriasis, rosacea, seborrheic dermatitis, skin cancer, xeroderma pigmentosum
Drug Side Effect	Acitretin, apraclonidine, atropine (systemic), betaxolol (systemic), bexarotene (systemic), brimonidine (ophthalmic), brinzolamide, cetuximab, clomipramine, difluprednate, dipivefrin, erythromycin and benzoyl peroxide topical (patient information), fluocinolone (ophthalmic), gatifloxacin, gefitinib, iloperidone, ipilimumab, isotretinoin, lansoprazole, lodoxamide tromethamine, loteprednol, methotrexate, metipranolol, mirtazapine, mupirocin, nisoldipine, nitisinone, pegaptanib, pentamidine (oral inhalation), pramipexole, pregabalin, quetiapine, ranibizumab, rasagiline, saquinavir, tacrolimus (topical), tiagabine, timolol (ophthalmic), travoprost, unoprostone, venlafaxine, verteporfin, zaleplon, ziprasidone
Ear Nose Throat	No underlying causes
Endocrine	Diabetes, glucagonoma syndrome
Environmental	No underlying causes
Gastroenterologic	Congenital erythropoietic porphyria, Crohn’s disease
Genetic	Congenital erythropoietic porphyria, dyskeratosis congenita, epidermolysis bullosa, lipoid proteinosis, myotonic dystrophy, xeroderma pigmentosum
Hematologic	Congenital erythropoietic porphyria
Iatrogenic	No underlying causes
Infectious Disease	Demodex, herpes simplex virus infection, HIV, lice, molluscum contagiosum, pediculosis, periorbital cellulitis, phthiriasis, propionibacterium acnes, pseudomonas aeruginosa, staphylococcus aureus, syphilis, varicella zoster
Musculoskeletal/Orthopedic	Myotonic dystrophy
Neurologic	Myotonic dystrophy
Nutritional/Metabolic	Lipoid proteinosis
Obstetric/Gynecologic	No underlying causes
Oncologic	Glucagonoma syndrome, skin cancer
Ophthalmologic	Atopic keratoconjunctivitis, chalazion, contact lens, dry eyes, dysfunctional meibomian glands, periorbital cellulitis, vernal keratoconjunctivitis
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Allergies, atopic dermatitis, atopic keratoconjunctivitis, chronic graft-versus-host disease, Sjögren’s syndrome
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Poor hygiene

Causes in Alphabetical Order

References

↑ ^1.0 ^1.1 Lemp MA, Nichols KK (2009). “Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment”. Ocul Surf. 7 (2 Suppl): S1–S14. PMID 19383269.
↑ ^2.0 ^2.1 Blepharitis. American Academy of Ophthalmology/eyewiki (2014). http://eyewiki.org/Blepharitis Accessed on July 14, 2016
↑ Bernardes TF, Bonfioli AA (2010). “Blepharitis”. Semin Ophthalmol. 25 (3): 79–83. doi:10.3109/08820538.2010.488562. PMID 20590417.
↑ ^4.0 ^4.1 ^4.2 McCulley JP, Dougherty JM (1986). “Bacterial aspects of chronic blepharitis”. Trans Ophthalmol Soc U K. 105 ( Pt 3): 314–8. PMID 3466455.
↑ ^5.0 ^5.1 Driver PJ, Lemp MA (1996). “Meibomian gland dysfunction”. Surv Ophthalmol. 40 (5): 343–67. PMID 8779082.
↑ Blepharitis. Diseases Database. (2016). http://www.diseasesdatabase.com/relationship.asp?glngUserChoice=1455&bytRel=2&blnBW=0&strBB=RL&blnClassSort=255 Accessed on July 15, 2016
↑ ^7.0 ^7.1 ^7.2 Auw-Haedrich C, Reinhard T (2007). “[Chronic blepharitis. Pathogenesis, clinical features, and therapy]”. Ophthalmologe. 104 (9): 817–26, quiz 827-8. doi:10.1007/s00347-007-1608-8. PMID 17762935.
↑ Dranko S, Kinney C, Ramanathan RK (2006). “Ocular toxicity related to cetuximab monotherapy in patients with colorectal cancer”. Clin Colorectal Cancer. 6 (3): 224–5. doi:10.3816/CCC.2006.n.040. PMID 17026793.
↑ Yilmaz S, Aydemir E, Maden A, Unsal B (2007). “The prevalence of ocular involvement in patients with inflammatory bowel disease”. Int J Colorectal Dis. 22 (9): 1027–30. doi:10.1007/s00384-007-0275-1. PMID 17262200.
↑ Biswas J, Sudharshan S (2008). “Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome”. Indian J Ophthalmol. 56 (5): 363–75. PMC 2636142. PMID 18711264.CS1 maint: PMC format (link)
↑ Karimian F, Zarei-Ghanavati S, A BR, Jadidi K, Lotfi-Kian A (2011). “Microbiological evaluation of chronic blepharitis among Iranian veterans exposed to mustard gas: a case-controlled study”. Cornea. 30 (6): 620–3. doi:10.1097/ICO.0b013e3181e16f7c. PMID 21282998.
↑ Rehal B, Modjtahedi BS, Morse LS, Schwab IR, Maibach HI (2011). “Ocular psoriasis”. J Am Acad Dermatol. 65 (6): 1202–12. doi:10.1016/j.jaad.2010.10.032. PMID 21550135.
↑ Brooks BP, Thompson AH, Bishop RJ, Clayton JA, Chan CC, Tsilou ET; et al. (2013). “Ocular manifestations of xeroderma pigmentosum: long-term follow-up highlights the role of DNA repair in protection from sun damage”. Ophthalmology. 120 (7): 1324–36. doi:10.1016/j.ophtha.2012.12.044. PMC 3702678. PMID 23601806.

[pmid19383269-1] 1.0 ^1.1 Lemp MA, Nichols KK (2009). “Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment”. Ocul Surf. 7 (2 Suppl): S1–S14. PMID 19383269.

[Blepharitis-1-2] 2.0 ^2.1 Blepharitis. American Academy of Ophthalmology/eyewiki (2014). http://eyewiki.org/Blepharitis Accessed on July 14, 2016

[pmid20590417-3] Bernardes TF, Bonfioli AA (2010). “Blepharitis”. Semin Ophthalmol. 25 (3): 79–83. doi:10.3109/08820538.2010.488562. PMID 20590417.

[pmid3466455-4] 4.0 ^4.1 ^4.2 McCulley JP, Dougherty JM (1986). “Bacterial aspects of chronic blepharitis”. Trans Ophthalmol Soc U K. 105 ( Pt 3): 314–8. PMID 3466455.

[pmid8779082-5] 5.0 ^5.1 Driver PJ, Lemp MA (1996). “Meibomian gland dysfunction”. Surv Ophthalmol. 40 (5): 343–67. PMID 8779082.

[blepharitis-2-6] Blepharitis. Diseases Database. (2016). http://www.diseasesdatabase.com/relationship.asp?glngUserChoice=1455&bytRel=2&blnBW=0&strBB=RL&blnClassSort=255 Accessed on July 15, 2016

[pmid17762935-7] 7.0 ^7.1 ^7.2 Auw-Haedrich C, Reinhard T (2007). “[Chronic blepharitis. Pathogenesis, clinical features, and therapy]”. Ophthalmologe. 104 (9): 817–26, quiz 827-8. doi:10.1007/s00347-007-1608-8. PMID 17762935.

[pmid17026793-8] Dranko S, Kinney C, Ramanathan RK (2006). “Ocular toxicity related to cetuximab monotherapy in patients with colorectal cancer”. Clin Colorectal Cancer. 6 (3): 224–5. doi:10.3816/CCC.2006.n.040. PMID 17026793.

[pmid17262200-9] Yilmaz S, Aydemir E, Maden A, Unsal B (2007). “The prevalence of ocular involvement in patients with inflammatory bowel disease”. Int J Colorectal Dis. 22 (9): 1027–30. doi:10.1007/s00384-007-0275-1. PMID 17262200.

[pmid18711264-10] Biswas J, Sudharshan S (2008). “Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome”. Indian J Ophthalmol. 56 (5): 363–75. PMC 2636142. PMID 18711264.CS1 maint: PMC format (link)

[pmid21282998-11] Karimian F, Zarei-Ghanavati S, A BR, Jadidi K, Lotfi-Kian A (2011). “Microbiological evaluation of chronic blepharitis among Iranian veterans exposed to mustard gas: a case-controlled study”. Cornea. 30 (6): 620–3. doi:10.1097/ICO.0b013e3181e16f7c. PMID 21282998.

[pmid21550135-12] Rehal B, Modjtahedi BS, Morse LS, Schwab IR, Maibach HI (2011). “Ocular psoriasis”. J Am Acad Dermatol. 65 (6): 1202–12. doi:10.1016/j.jaad.2010.10.032. PMID 21550135.

[pmid23601806-13] Brooks BP, Thompson AH, Bishop RJ, Clayton JA, Chan CC, Tsilou ET; et al. (2013). “Ocular manifestations of xeroderma pigmentosum: long-term follow-up highlights the role of DNA repair in protection from sun damage”. Ophthalmology. 120 (7): 1324–36. doi:10.1016/j.ophtha.2012.12.044. PMC 3702678. PMID 23601806.

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Blepharitis causes

Overview

Causes

Causes by Organ System

Causes in Alphabetical Order

References

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