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Boceprevir contraindications
Introduction
Contraindications
Contraindications
Contraindications to peginterferon alfa and ribavirin also apply to VICTRELIS combination treatment.
VICTRELIS in combination with peginterferon alfa and ribavirin is contraindicated in:
Pregnant women and men whose female partners are pregnant because of the risks for birth defects and fetal death associated with ribavirin [see Warnings and Precautions (5.1) and Use in Specific Populations (8.1)]. Patients with a history of a hypersensitivity reaction to boceprevir [see Warnings and Precautions (5.4)].
Coadministration with drugs that are highly dependent on CYP3A4/5 for clearance, and for which elevated plasma concentrations are associated with serious and/or life-threatening events, including those in Table 2, is contraindicated [see also Drug Interactions (7)].
Coadministration with potent CYP3A4/5 inducers, where significantly reduced boceprevir plasma concentrations may be associated with reduced efficacy, including those inTable 2, is contraindicated [see also Drug Interactions (7)].
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References
References
- ↑ “http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202258s001lbl.pdf” (PDF). External link in
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Adapted from the FDA Package Insert.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]