Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Bone or cartilage mass biopsy
Introduction
Overview
Overview
Bone biopsy findings associated with bone and cartilage tumors will depend on tumor histology, common findings include: anastomosing bony trabeculae, calcifications surrounded by cells nests, and increased/decreased osteoblasts and osteoclasts.[1]
Biopsy
Biopsy
Common types of bone biopsy, include:[1][2]
- Open
- Performed during surgery
- Diagnostic accuracy is similar to closed biopsy.
- On malignant lesions, biopsy incisions are: longitudinal, small, or anatomically placed to minimize contamination of normal tissue
- Increased risk of complications
- Tissue biopsy analyzed for bacterial and fungal culture, because bone infections may mimic a bone tumor
- Closed
- Initial biopsy in most bone and cartilage tumors.
- Less invasive and lower risk of tissue contamination with tumor cells
- Usually involves CT image-guided percutaneous biopsy
- Less risk of complications
- Biopsy in tumors that are predominantly cystic or with fluid levels (likely to result in nondiagnostic results)
- Less painful, and less costly
- Disadvantages, include: insufficient tissue from lesions and erroneous diagnosis of tumor grade
- Common bone and cartilage tumors biopsy findings, include:
- Anastomosing bony trabeculae
- Calcifications surrounded by cells nests
- Increased/decreased osteoblasts and osteoclasts
References
References
- ↑ 1.0 1.1 Mankin HJ, Lange TA, Spanier SS (2006). “THE CLASSIC: The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors. The Journal of Bone and Joint Surgery, 1982;64:1121-1127”. Clin. Orthop. Relat. Res. 450: 4–10. doi:10.1097/01.blo.0000229299.36969.b5. PMID 16951637.
- ↑ Jelinek JS, Murphey MD, Welker JA, Henshaw RM, Kransdorf MJ, Shmookler BM, Malawer MM (2002). “Diagnosis of primary bone tumors with image-guided percutaneous biopsy: experience with 110 tumors”. Radiology. 223 (3): 731–7. doi:10.1148/radiol.2233011050. PMID 12034942.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]