Bone or cartilage mass biopsy

Bone biopsy findings associated with bone and cartilage tumors will depend on tumor histology, common findings include: anastomosing bony trabeculae, calcifications surrounded by cells nests, and increased/decreased osteoblasts and osteoclasts.^[1]

Common types of bone biopsy, include:^[1][2]

• Open

• Performed during surgery
• Diagnostic accuracy is similar to closed biopsy.
• On malignant lesions, biopsy incisions are: longitudinal, small, or anatomically placed to minimize contamination of normal tissue
• Increased risk of complications
• Tissue biopsy analyzed for bacterial and fungal culture, because bone infections may mimic a bone tumor

• Closed

• Initial biopsy in most bone and cartilage tumors.
• Less invasive and lower risk of tissue contamination with tumor cells
• Usually involves CT image-guided percutaneous biopsy
• Less risk of complications
• Biopsy in tumors that are predominantly cystic or with fluid levels (likely to result in nondiagnostic results)
• Less painful, and less costly
• Disadvantages, include: insufficient tissue from lesions and erroneous diagnosis of tumor grade

• Common bone and cartilage tumors biopsy findings, include:

• Anastomosing bony trabeculae
• Calcifications surrounded by cells nests
• Increased/decreased osteoblasts and osteoclasts