Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Bovine spongiform encephalopathy laboratory findings
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Leystad), the detection of Scrapie-Associated Fibrils in the brain tissue (by electron microscopy), and specific histopathologic findings such as vacuolation of neurons and neuropil.
Laboratory Findings
Laboratory Findings
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include:[1][2]
- Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad)
- Vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen
- Detection of Scrapie-Associated Fibrils (by electron microscopy)
References
References
- ↑ van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA (2000). “Diagnosis of bovine spongiform encephalopathy: a review”. Vet Q. 22 (4): 197–200. doi:10.1080/01652176.2000.9695057. PMID 11087129.
- ↑ “MANUAL ON BOVINE SPONGIFORM ENCEPHALOPATHY”.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Â ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]