Bradycardia historical perspective

Jan Evangelista Purkinje found a net of gelatinous fibers in the subendocardium of the heart in 1839. Later on, in the 1880s, Walter Gaskell found that the region where the cardiac impulse generated was near the sinus venosus. The conduction bundle, which links the sinus node and AV node, was found by Wilhelm His Jr in 1893. In 1906, Sunao tawara assumed that a tissue present at the proximal end of his bundle was the beginning of an electrical conducting system, which proceeded from the AV node through the bundle of His, separated into the bundle branches, and ended up as the purkinje fibers. In the same year, Flack and Keith made the first observation of the mammalian sinoatrial node (SAN).

• Gelatinous fibers in the subendocardium was first discovered by Jan Evangelista Purkinje, in 1839.^[1]
• Later on, in the 1880s, Walter Gaskell found that the region where the cardiac impulse generated was near the sinus venosus.
• Conduction bundle which links the sinus node and AV node was found by Wilhelm His Jr in 1893.
• In 1906, Sunao tawara assumed that a tissue present at the proximal end of his bundle was the beginning of an electrical conducting system, which proceeded from the AV node through the bundle of His, separated into the bundle branches, and ended up as the purkinje fibers.^[2]
• In the same year Flack and Keith made the first observation of the mammalian sinoatrial node (SAN).^[3]

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